Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

Huayun Deng; Haibei Hu; Shizhang Ling; Ann M Ferrie; Ye Fang

doi:10.1021/ml2003058

Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

ACS Med Chem Lett. 2012 Jan 17;3(2):165-9. doi: 10.1021/ml2003058. eCollection 2012 Feb 9.

Authors

Huayun Deng¹, Haibei Hu¹, Shizhang Ling¹, Ann M Ferrie¹, Ye Fang¹

Affiliation

¹ Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, United States.

Abstract

We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango β-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.

Keywords: GPR35; biased agonism; ellagic acid; natural phenols.